Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study-Reference-Cited by-同舟云学术

Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study

Published:2021-12 Issue:12 Volume:21 Page:1713-1724
ISSN:1473-3099
Container-title:The Lancet Infectious Diseases
language:en
Short-container-title:The Lancet Infectious Diseases

Author:

McCarthy James S,Yalkinoglu Özkan,Odedra Anand,Webster Rebecca,Oeuvray Claude,Tappert Aliona,Bezuidenhout Deon,Giddins Marla J,Dhingra Satish K,Fidock David A,Marquart Louise,Webb Lachlan,Yin Xiaoyan,Khandelwal Akash,Bagchus Wilhelmina M

Funder

Merck KGaA

Wellcome Trust

Publisher

Elsevier BV

Subject

Infectious Diseases

Reference26 articles.

1. World malaria report,2020

2. The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study;Imwong;Lancet Infect Dis,2017

3. Designing the next generation of medicines for malaria control and eradication;Burrows;Malar J,2013

4. A novel multiple-stage antimalarial agent that inhibits protein synthesis;Baragana;Nature,2015

5. Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy;Baragana;J Med Chem,2016

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