Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial

Author:

Scriba Thomas J,Fiore-Gartland Andrew,Penn-Nicholson Adam,Mulenga Humphrey,Kimbung Mbandi Stanley,Borate Bhavesh,Mendelsohn Simon C,Hadley Katie,Hikuam Chris,Kaskar Masooda,Musvosvi Munyaradzi,Bilek Nicole,Self Steven,Sumner Tom,White Richard G,Erasmus Mzwandile,Jaxa Lungisa,Raphela Rodney,Innes Craig,Brumskine William,Hiemstra Andriëtte,Malherbe Stephanus T,Hassan-Moosa Razia,Tameris Michèle,Walzl Gerhard,Naidoo Kogieleum,Churchyard Gavin,Hatherill Mark,Baepanye Kesenogile,Baepanye Tshepiso,Clarke Ken,Collignon Marelize,Dlamini Audrey,Eyre Candice,Feni Tebogo,Fikizolo Moogo,Galane Phinda,Goliath Thelma,Gangat Alia,Malefo-Grootboom Shirley,Janse van Rensburg Elba,Janse van Rensburg Bonita,Kekana Sophy,Zietsman Marietjie,Kock Adrianne,Kunene Israel,Lakhi Aneessa,Langa Nondumiso,Ledwaba Hilda,Luphoko Marillyn,Mabasa Immaculate,Mabe Dorah,Mabuza Nkosinathi,Majola Molly,Makhetha Mantai,Makoanyane Mpho,Makhubalo Blossom,Malay Vernon,Market Juanita,Matshego Selvy,Mbipa Nontsikelelo,Mmotsa Tsiamo,Modipa Sylvester,Mopati Samuel,Moswegu Palesa,Mothaga Primrose,Muller Dorothy,Nchwe Grace,Nel Maryna,Nhlangulela Lindiwe,Ntamo Bantubonke,Ntoahae Lawerence,Ntshauba Tedrius,Sanyaka Nomsa,Seabela Letlhogonolo,Selepe Pearl,Senne Melissa,Serake MG,Thlapi Maria,Tshikovhi Vincent,Tswaile Lebogang,van Aswegen Amanda,Mbata Lungile,Takavamanya Constance,Pinho Pedro,Mdlulu John,Taljaard Marthinette,Slabbert Naydene,Sayed Sharfuddin,Nielson Tanya,Senne Melissa,Ni Sein Ni,Mbata Lungile,Govender Dhineshree,Chinappa Tilagavathy,Zulu Mbali Ignatia,Maphanga Nonhle Bridgette,Hlathi Senzo Ralph,Gumede Goodness Khanyisile,Shezi Thandiwe Yvonne,Maphanga Jabulisiwe Lethabo,Jali Zandile Patrica,Cwele Thobelani,Gwamanda Nonhlanhla Zanele Elsie,Dlamini Celaphiwe,Sing Zibuyile Phindile Penlee,Ntanjana Ntombozuko Gloria,Nzimande Sphelele Simo,Mbatha Siyabonga,Maharaj Bhavna,Moosa Atika,Corris Cara-Mia,Kafaar Fazlin,Geldenhuys Hennie,Luabeya Angelique Kany Kany,Shenje Justin,Botes Natasja,Rossouw Susan,Africa Hadn,Diamond Bongani,Braaf Samentra,Stryers Sonia,Carstens Alida,Jansen Ruwiyda,Mabwe Simbarashe,Mulenga Humphrey,Herling Roxane,Veldsman Ashley,Makhete Lebohgang,Steyn Marcia,Buhlungu Sivuyile,Erasmus Margareth,Davids Ilse,Plaatjie Patiswa,Companie Alessandro,Ratangee Frances,Veldtsman Helen,Petersen Christel,Abrahams Charmaine,Moses Miriam,Kelepu Xoliswa,Gregg Yolande,Swanepoel Liticia,Magawu Nomsitho,Cetywayo Nompumelelo,Mactavie Lauren,Valley Habibullah,Filander Elizabeth,Nqakala Nambitha,Maasdorp Elizna,Khoury Justine,Kriel Belinda,Smith Bronwyn,Muller Liesel,Tonsing Susanne,Loxton Andre,Hiemstra Andriette,Ahlers Petri,Flinn Marika,Chung Eva,Chung Michelle,Sato Alicia

Funder

South African Medical Research Council

Bill and Melinda Gates Foundation

Publisher

Elsevier BV

Subject

Infectious Diseases

Reference21 articles.

1. Is Mycobacterium tuberculosis infection life long?;Behr;BMJ,2019

2. Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention;Fiore-Gartland;Tuberculosis,2018

3. Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis;Petruccioli;Eur Respir J,2016

4. Potential population level impact on tuberculosis incidence of using an mRNA expression signature correlate-of-risk test to target tuberculosis preventive therapy;Sumner;Sci Rep,2019

5. High-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting,2014

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