Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial

Author:

Jones Allison R.ORCID,Patel Rakesh P.,Marques Marisa B.,Donnelly John P.,Griffin Russell L.,Pittet Jean-Francois,Kerby Jeffrey D.,Stephens Shannon W.,DeSantis Stacia M.,Hess John R.,Wang Henry E.,Holcomb John B.,Wade Charles E.,del Junco Deborah J.,Fox Erin E.,Matijevic Nena,Podbielski Jeanette,Beeler Angela M.,Tilley Barbara C.,Baraniuk Sarah,Zhu Hongjian,Nixon Joshua,Seay Roann,Appana Savitri N.,Yang Hui,Gonzalez Michael O.,Baer Lisa,Wang Yao-Wei W.,Hula Brittany S.,Espino Elena,Nguyen An,Pawelczyk Nicholas,Arora-Nutall Kisha D.,Sharma Rishika,Cardenas Jessica C.,Rahbar Elaheh,Burnett Tyrone,Clark David,van Belle Gerald,May Susanne,Leroux Brian,Hoyt David,Powell Judy,Sheehan Kellie,Hubbard Alan,Arkin Adam P.,Hess John R.,Callum Jeanne,Cotton Bryan A.,Vincent Laura,Welch Timothy,Poole Tiffany,Pivalizza Evan G.,Gumbert Sam D.,Bai Yu,McCarthy James J.,Noland Amy,Hobbs Rhonda,Bulger Eileen M.,Klotz Patricia,Cattin Lindsay,Warner Keir J.,Wilson Angela,Boman David,White Nathan,Grabinsky Andreas,Daniel-Johnson Jennifer A.,Cohen Mitchell J.,Callcut Rachael A.,Nelson Mary,Redick Brittney,Conroy Amanda,Steurer Marc P.,Maxim Preston C.,Fiebig Eberhard,Moore Joanne,Mallari Eireen,Muskat Peter,Johannigman Jay A.,Robinson Bryce R.H.,Branson Richard D.,Gomaa Dina,Barczak Christopher,Bennett Suzanne,Carey Patricia M.,Miller Christopher N.,Hancock Helen,Rodriguez Carolina,Inaba Kenji,Zhu Jay G.,Wong Monica D.,Menchine Michael,Katzberg Kelly,Henderson Sean O.,McKeever Rodney,Shulman Ira A.,Nelson Janice M.,Tuma Christopher W.,Matsushita Cheryl Y.,Scalea Thomas M.,Stein Deborah M.,Shaffer Cynthia K.,Wade Christine,Herrera Anthony V.,Kallam Seeta,Wade Sarah E.,Galvagno Samuel M.,Fontaine Magali J.,Hunt Janice M.,Cooke Rhonda K.,Fabian Timothy C.,Weinberg Jordan A.,Croce Martin A.,Wilson Suzanne,Panzer-Baggett Stephanie,Waddle-Smith Lynda,Flax Sherri,Brasel Karen J.,Walsh Pamela,Milia David,Nelson Allia,Kaslow Olga,Aufderheide Tom P.,Gottschall Jerome L.,Carpenter Erica,O’Keeffe Terence,Rokowski Laurel L.,Denninghoff Kurt R.,Redford Daniel T.,Novak Deborah J.,Knoll Susan,Kerby Jeffrey D.,Pittet Jean-Francois,Bosarge Patrick L.,Pierce Albert T.,Williams Carolyn R.,Stephens Shannon W.,Wang Henry E.,Marques Marisa B.,Schreiber Martin A.,Watters Jennifer M.,Underwood Samantha J.,Groat Tahnee,Newgard Craig,Merkel Matthias,Scanlan Richard M.,Miller Beth,Rizoli Sandro,Tien Homer,Nascimento Barto,Trpcic Sandy,Sobrian-Couroux Skeeta,Reis Marciano,Pérez Adic,Belo Susan E.,Merkley Lisa,Colavecchia Connie

Funder

National Heart, Lung, and Blood Institute

Department of Defense, and Defence Research and Development Canada

Canadian Institutes of Health Research, Institute of Circulatory and Respiratory Health

Publisher

Elsevier BV

Subject

Emergency Medicine

Reference29 articles.

1. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations;Kauvar;J Trauma,2006

2. The pathophysiology and consequences of red blood cell storage;Orlov;Anaesthesia,2015

3. Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements;Oh;Transfusion,2015

4. Measures of stored red blood cell quality;Hess;Vox Sang,2014

5. Distinct roles of trauma and transfusion in induction of immune modulation after injury;Jackman;Transfusion,2012

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