A dihydropyridine conjugate which generates high and sustained levels of the corresponding pyridinium salt in the brain does not exhibit neurotoxicity in cynomolgus monkeys-Reference-Cited by-同舟云学术

A dihydropyridine conjugate which generates high and sustained levels of the corresponding pyridinium salt in the brain does not exhibit neurotoxicity in cynomolgus monkeys

Published:1988-05 Issue:3 Volume:87 Page:277-282
ISSN:0304-3940
Container-title:Neuroscience Letters
language:en
Short-container-title:Neuroscience Letters

Author:

Brewster Marcus E.,Estes Kerry S.,Perchalski Robert,Bodor Nicholas

Publisher

Elsevier BV

Subject

General Neuroscience

Reference16 articles.

1. Parkinson-like syndrome in nonhuman primates receiving a tetrahydropyridine derivative;Barsoum;Neurotoxicology,1986

2. Problems of delivery of drugs of the brain;Bodor;Pharmacol. Toxicol.,1983

3. The toxic actions of MPTP and its metabolite MPP+ are not mimicked by analogues of MPTP lacking an N-methyl moiety;Bradbury;Neurosci. Lett.,1985

4. Improved delivery through biological membranes. XXIV. Synthesis, in vitro studies and in vivo characterization of brain-specific and sustained progestin delivery systems;Brewster;Pharm. Res.,1986

5. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Burns,1983

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