An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions

Author:

Nagatsu Toshiharu,Yoshida Mitsuo

Publisher

Elsevier BV

Subject

General Neuroscience

Reference10 articles.

1. A primate model of Parkinson's disease: selective destruction of dopaminergic neurons in the pars compacta of substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Burns,1983

2. Chronic parkinsonism secondary to intravenous injection of meperidine analogues;Davis;Psychiatry Res.,1979

3. Analysis of reduced forms of biopterin in biological tissues and fluids;Fukushima;Anal. Biochem.,1980

4. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6,-tetrahydropyridine in mice;Heikkila;Science,1984

5. Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain;Kohno;Biochem. Biophys. Res. Commun.,1986

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