Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity

Author:

Turley Joanna L.,Ward Ross W.,Huete-Carrasco Jorge,Muñoz-Wolf Natalia,Roche Kate,Jin Lei,Bowie Andrew,Andersson Mats,Lavelle Ed C.ORCID

Funder

Irish Research Council

Hearing Industry Research Consortium

Science Foundation Ireland

Publisher

Elsevier BV

Reference63 articles.

1. Host type I IFN signals are required for antitumor CD8 + T cell responses through CD8α + dendritic cells;Fuertes;J. Exp. Med.,2011

2. Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy;Zheng;Mol. Cancer,2020

3. NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking;Zhang;Cell Rep.,2023

4. TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections;Yum;Proc. Natl. Acad. Sci. USA,2021

5. Trial watch: STING agonists in cancer therapy;Le Naour;OncoImmunology,2020

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