Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy

Author:

St. Paul MichaelORCID,Saibil Samuel D.,Kates Meghan,Han SeongJun,Lien Scott C.,Laister Rob C.,Hezaveh Kebria,Kloetgen Andreas,Penny Susanne,Guo Tingxi,Garcia-Batres Carlos,Smith Logan K.,Chung Douglas C.,Elford Alisha R.,Sayad Azin,Pinto Devanand,Mak Tak W.,Hirano Naoto,McGaha Tracy,Ohashi Pamela S.

Funder

Canadian Institutes of Health Research

Publisher

Elsevier BV

Reference51 articles.

1. Adoptive cellular therapies: the current landscape;Rohaan;Virchows Arch.,2019

2. Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis;Dafni;Ann. Oncol.,2019

3. Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts;Chesney;J. Immunother. cancer,2022

4. Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma;Rohaan;N. Engl. J. Med.,2022

5. Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma;Neelapu;N. Engl. J. Med.,2017

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