Excitotoxicity and ALS: New therapy targets an old mechanism

Author:

Smith Hannah Louise,Chaytow Helena,Gillingwater Thomas Henry

Funder

Novartis

Roche

Publisher

Elsevier BV

Reference10 articles.

1. TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS;Yan;Cell Rep Med,2024

2. Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis;Goutman;Lancet Neurol.,2022

3. Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation;Mead;Nat. Rev. Drug Discov.,2023

4. The pharmacology and mechanism of action of riluzole;Doble;Neurology,1996

5. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants;Yan;Science,2020

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