Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing

Author:

Liu Chuan,Leighow Scott M.ORCID,McIlroy Kyle,Lu Mengrou,Dennis Kady A.,Abello Kerry,Brown Donovan J.,Moore Connor J.,Shah Anushka,Inam Haider,Rivera Victor M.,Pritchard Justin R.

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference49 articles.

1. Innovation in the pharmaceutical industry: New estimates of R&D costs;DiMasi;J. Health Econ.,2016

2. Clinical development success rates for investigational drugs;Hay;Nat. Biotechnol.,2014

3. Drug repurposing: Progress, challenges and recommendations;Pushpakom;Nat. Rev. Drug Discov.,2019

4. Renovation as innovation: is repurposing the future of drug discovery research?;Neuberger;Drug Discov. Today,2019

5. Phase III trial failures: costly, but preventable;Grignolo;Appl. Clin. Trials,2016

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