Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines

Author:

Shaw Robert H.,Greenland Melanie,Stuart Arabella S.V.,Aley Parvinder K.,Andrews Nick J.,Cameron J. ClaireORCID,Charlton SueORCID,Clutterbuck Elizabeth A.,Collins Andrea M.,Darton Tom,Dinesh Tanya,Duncan Christopher J.A.,Faust Saul N.,Ferreira Daniela M.,Finn Adam,Goodman Anna L.,Green Christopher A.,Hallis Bassam,Heath Paul T.,Hill Helen,Lambe Teresa,Libri VincenzoORCID,Lillie Patrick J.,Morey Ella,Mujadidi Yama F.,Payne Ruth,Plested Emma L.,Provstgaard-Morys Samuel,Ramasamy Maheshi N.,Ramsay Mary,Read Robert C.,Robinson Hannah,Screaton Gavin R.,Singh NishaORCID,Turner David P.J.,Turner Paul J.,White Rachel,Nguyen-Van-Tam Jonathan S.,Liu Xinxue,Snape Matthew D.

Publisher

Elsevier BV

Subject

Infectious Diseases,Microbiology (medical)

Reference13 articles.

1. Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis [Internet]. Vol. 22(no. 9); 2022 [cited 2022 Oct 3], p. 1293–302. Available from: 〈http://www.thelancet.com/article/S1473309922003206/fulltext〉.

2. Coronavirus (COVID-19) vaccinations – statistics and research [internet];Our World Data,2021

3. Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial;Stuart;Lancet,2021

4. University of Oxford. COM-CoV3 Study website [Internet]; 2021 [cited 2022 Oct 23]. Available from: 〈https://comcovstudy.org.uk/about-com-cov3〉.

5. Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial;Shaw;Lancet Respir Med,2022

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