High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates

Author:

Hows Mark E.P,Ashmeade Tracey E,Billinton Andrew,Perren Marion J,Austin Angela A,Virley David J,Organ Andrew J,Shah Ajit J

Publisher

Elsevier BV

Subject

General Neuroscience

Reference21 articles.

1. In vivo hydroxylation of the neurotoxin 1-methyl-4-phenylpyridinium, and the effect of monoamine oxidase inhibitors: electrospray analysis of intra-striatal microdialysates;Boismenu;J. Mass Spectrom.,1996

2. Liquid chromatography-mass spectrometry with ionspray and electrospray interfaces in pharmaceutical and biomedical research;Bruins;J. Chromatogr.,1991

3. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase;Chiba;Biochem. Biophys. Res. Commun.,1984

4. Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice;Giovanni;J. Pharmacol. Exp. Ther.,1991

5. Analysis of neurotoxic metabolite derived from haloperidol in biological samples using LC-APCI/MS and LC-ESI/MS;Igarashi;Nippon Iyo Masu Supekutoru Gakki Koenshu,1994

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