PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma

Author:

Smeester Branden A.,Slipek Nicholas J.,Pomeroy Emily J.,Laoharawee Kanut,Osum Sara H.,Larsson Alex T.,Williams Kyle B.,Stratton Natalie,Yamamoto Kenta,Peterson Joseph J.,Rathe Susan K.,Mills Lauren J.,Hudson Wendy A.,Crosby Margaret R.,Wang Minjing,Rahrmann Eric P.,Moriarity Branden S.,Largaespada David A.

Funder

Genentech, Inc.

NIH

University of Minnesota

Boston Children's Hospital

Zach Sobiech OSA Fund Award

Randy Shaver Cancer Research and Community Fund

Aflac-AACR

Children's Cancer Research Fund

American Cancer Society

Publisher

Elsevier BV

Subject

Histology,Physiology,Endocrinology, Diabetes and Metabolism

Reference42 articles.

1. Osteosarcoma: a comprehensive review;Misaghi;SICOT J,2018

2. Review of osteosarcoma and current management;Durfee;Rheumatol Ther,2016

3. Genome-wide analyses on high-grade osteosarcoma: making sense of a genomically most unstable tumor;Kuijjer;Int. J. Cancer,2013

4. Genome-informed targeted therapy for osteosarcoma;Sayles;Cancer Discovery,2019

5. Osteosarcoma: accelerating progress makes for a hopeful future;Saraf;Front. Oncol.,2018

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