An in-situ forming implant formulation of naltrexone with minimum initial burst release using mixture of PLGA copolymers and ethyl heptanoate as an additive: In-vitro, ex-vivo, and in-vivo release evaluation

Author:

Kamali Hossein,Khodaverdi Elham,Hadizadeh Farzin,Yazdian-Robati Rezvan,Haghbin Ali,Zohuri Golamhossein

Funder

Research Council of Mashhad University of Medical Sciences

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference56 articles.

1. Sustained-release naltrexone: novel treatment for opioid dependence;Comer;Expet Opin. Invest. Drugs,2007

2. Blood naltrexone levels over time following naltrexone implant;Ngo;Prog. Neuro-Psychopharmacol. Biol. Psychiatry,2008

3. Histological changes over time around the site of sustained release naltrexone-poly (DL-lactide) implants in humans;Hulse;J. Contr. Release,2005

4. Open label trial of naltrexone implants: measuring blood serum levels of naltrexone;Colquhoun;Subst. Abuse Res. Treat.,2013

5. A ‘biorelevant’system to investigate in vitro drug released from a naltrexone implant;Iyer;Int. J. Pharm.,2007

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