Abstract
“Aude Sapere” “Dare to Know—HoraceThe first part of this three-part series deals with the history of the recognition of the origins of cancer in specific, mainly chemical, environmental factors; and the rapid advances made this century in identifying carcinogens and elucidating their modes of action. I will then go on to review, briefly, the most important groups of carcinogenic chemicals, their in-vivo activation and common mode of action.The second article will start with the cytotoxic drugs and demonstrate that the distinction between them and chemical carcinogens is arbitrary. I will also consider co-carcinogens and the carcinogenic action of UV light and the importance of these phenomena in understanding the genesis of cancer.Finally, I will look at the linked processes of resistance to cytotoxic drugs, defences against carcinogens and DNA repair processes which it may be possible to turn to therapeutic advantage.
Subject
Complementary and alternative medicine,Pharmacology
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