Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4+T cells of aged rats

Author:

Gong Zhangbin,Liu Te,Wan Yinhan,Hang Zhifeng,Tong Xiaopeng,Zhang Bei,Yang Haozheng,Zhang Xueli,Zhang Lina,Jin GuoqinORCID

Publisher

Elsevier BV

Subject

Molecular Biology,Immunology

Reference22 articles.

1. Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity;Adolfsson;J. Immunol.,2001

2. In-vivo regulation of interleukin-2 receptor-alpha gene-transcription by the coordinated binding of constitutive and inducible factors in human primary T-cells;Algarte;EMBO J.,1995

3. Aged T-cells are hyporesponsive to costimulation mediated by Cd28;Engwerda;J. Immunol.,1994

4. Basal and induced amounts of interleukin-6 messenger-RNA decline progressively with age in human fibroblasts;Goodman;J. Biol. Chem.,1994

5. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo;Haynes;J. Immunol.,2004

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