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Enhanced antiviral benefit of combination therapy with anti-HBV and anti-PD1 gRNA/cas9 produces a synergistic antiviral effect in HBV infection

  • Published:2021-02 Issue: Volume:130 Page:7-13
  • ISSN:0161-5890
  • Container-title:Molecular Immunology
  • language:en
  • Short-container-title:Molecular Immunology

Author:

Zhen ShuaiORCID,Qiang Rong,Lu Jiaojiao,Tuo Xiaoqian,Yang Xiling,Li Xu

Funder

National Natural Science Foundation of China

Key Research and Development Program of Shaanxi Province of China

Special Talent Training Program in Northwest Women and Children Hospital

Publisher

Elsevier BV

Subject

Molecular Biology,Immunology

Reference42 articles.

1. The role of cccDNA in HBV maintenance;Allweiss;Viruses,2017

2. Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function;Belloni;Proc. Natl. Acad. Sci. U. S. A.,2009

3. IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome;Belloni;J. Clin. Invest.,2012

4. A T7 endonuclease I assay to detect talen-mediated targeted mutation of HBV cccDNA;Bloom;Methods Mol. Biol.,2017

5. Gene therapy for chronic HBV-can we eliminate cccDNA?;Bloom;Genes (Basel),2018
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