Preparation, preliminary pharmacokinetic and brain targeting study of metformin encapsulated W/O/W composite submicron emulsions promoted by borneol

Author:

Hong Lufeng,Li Xin,Bao Youmei,Duvall Craig L.,Zhang Caiyun,Chen Weidong,Peng Can

Funder

National Natural Science Foundation of China

Natural Science Foundation of Anhui Province

University excellent top-notch personnel training fund of Anhui Province

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference45 articles.

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2. Bornstein, S., Moschetta, M., Kawano, Y., et al. 2017. Metformin affects cortical bone mass and marrow adiposity in diet-induced obesity in male mice. Endocrinology. 158 (10), 3369–3385.

3. Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration;Cai;J. Drug Target.,2008

4. (+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines;Chang;J. Biomed. Res.,2017

5. Metformin ameliorates hypoxia/reoxygenation-induced cardiomyocyte apoptosis based on the SIRT3 signaling pathway;Du;Gene,2017

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