In vitro characterization of ritonavir formulations and correlation to in vivo performance in dogs

Author:

Xu Hao,Krakow Silvia,Shi Yi,Rosenberg Joerg,Gao PingORCID

Funder

AbbVie Inc.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference42 articles.

1. Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations;Alhalaweh;J. Control. Release,2016

2. Active apical secretory efflux of the HIV protose inhibitos saquinavir and ritonavir in Caco-2 cell monolayers;Alsenz;Pharm. Res.,1998

3. Anon n.d. The in vivo scaling factor, A/V, in dogs is estimated to be in the range of 4 to 26 cm-1 as reported in Deanna Mudie Ph.D. Thesis, University of Michigan, 2014. The average of A/V in dogs is estimated to be 6.8 cm-1 based on the degree of flatness of 1.7 (from K. Sugano). Theoretical investigation of passive intestinal membrane permeability using Monte Carlo method to generate drug-like molecule population. Int. J. Pharm. 373: 55–61 (2009). Estimation of a scaling factor, A/V, in dogs from private communication with Drs. Deanna Muddie and Greory Amidon.

4. The influence of donor and reservoir additives on Caco-2 permeability and secretory transport of HIV protease inhibitors and other lipophilic compounds;Aungst;Pharm. Res.,2000

5. Polymeric amorphous solid dispersions: a review of amorphization, crystallization, stabilization, solid-state characterization, and aqueous solubilization of biopharmaceutical classification system class II drugs;Baghel;J. Pharm. Sci.,2016

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