Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone

Author:

Mäntylä Antti,Rautio Jarkko,Nevalainen Tapio,Keski-Rahkonen Pekka,Vepsälainen Jouko,Järvinen Tomi

Publisher

Elsevier BV

Subject

Pharmaceutical Science

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5. N-Hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes;Clement;Drug Metab. Dispos.,1994

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