Synthesis and structure‑activity‑relationship of 3,4‑Diaryl‑1H‑pyrrolo[2,3‑b]pyridines as irreversible Inhibitors of mutant EGFR‑L858R/T790M-Reference-Cited by-同舟云学术

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Synthesis and structure‑activity‑relationship of 3,4‑Diaryl‑1H‑pyrrolo[2,3‑b]pyridines as irreversible Inhibitors of mutant EGFR‑L858R/T790M

Published:2019-02 Issue: Volume:128 Page:91-96
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Günther Marcel,Laux Julian,Laufer Stefan^ORCID

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference25 articles.

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2. Computer‑aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole‑3‑carbinol to block Akt signaling;Chao;J. Med. Chem.,2007

3. Osimertinib: a novel dermatologic adverse event profile in patients with lung cancer;Chu;Oncologist,2018

4. AZD9291, an irreversible EGFR TKI, overcomes T790M‑mediated resistance to EGFR inhibitors in lung cancer;Cross;Cancer Discov.,2014

5. A high‑throughput radiometric kinase assay;Duong‑Ly;Methods Mol. Biol.,2016

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