Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics-Reference-Cited by-同舟云学术

Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics

Published:2023-07 Issue: Volume:186 Page:106450
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Lu Dan^ORCID,Yadav Rajbharan,Holder Patrick,Chiang Eugene,Sanjabi Shomyseh,Poon Victor,Bernett Matthew,Varma Rajat,Liu Ke,Leung Irene,Bogaert Liz,Desjarlais John,Shivva Vittal,Hosseini Iraj,Ramanujan Saroja

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference46 articles.

1. Translational quantitative systems pharmacology in drug development: from current landscape to good practices;Bai;AAPS J.,2019

2. Short lifespans of memory T-cells in bone marrow, blood, and lymph nodes suggest that T-cell memory is maintained by continuous self-renewal of recirculating cells;Baliu-Piqué;Front. Immunol.,2018

3. Abstract 5565: Potency-reduced IL15/IL15Rα heterodimeric Fc-fusions display enhanced in vivo activity through increased exposure;Bernett;Cancer Res.,2018

4. 2018. An IL15/IL15R.... heterodimeric Fc-fusion engineered for reduced potency demonstrates an optimal balance of in vivo activity and exposure;Bernett,2018

5. NK cell exhaustion;Bi;Front. Immunol.,2017

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges;Clinical Pharmacokinetics;2024-06-18

2. Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy;Frontiers in Pharmacology;2024-06-03

3. A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule;Pharmaceutics;2024-05-15

4. IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion;Molecular Cancer Therapeutics;2024-05-10

5. Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics;npj Systems Biology and Applications;2024-03-18