A myth of the well-stirred model: Is the well-stirred model good for high clearance drugs?
Author:
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference14 articles.
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1. Introducing the Dynamic Well-Stirred Model for Predicting Hepatic Clearance and Extraction Ratio;Journal of Pharmaceutical Sciences;2024-04
2. Use of Clearance Concepts to Simulate Impact of Interleukin-6 on Drug Elimination Governed by Cytochromes P450 3A4 and Glomerular Filtration Rate;European Journal of Drug Metabolism and Pharmacokinetics;2023-10-04
3. Physiologically Based Pharmacokinetic Modelling in Drug Discovery and Clinical Development: A Treatise on Concepts, Model Workflow, Credibility, Application and Regulatory Landscape;The Quintessence of Basic and Clinical Research and Scientific Publishing;2023
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