Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport-Reference-Cited by-同舟云学术

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Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport

Published:2024-12 Issue: Volume:203 Page:106883
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Zhang Mengxu^ORCID,Vuist Ilona M.,Rottschäfer Vivi,de Lange Elizabeth CM^ORCID

Funder

China Scholarship Council

Publisher

Elsevier BV

Reference44 articles.

1. Monolix 2021R2. Lixoft SAS, a Simulations Plus company.

2. Sycomore 2021R2. Lixoft SAS, a Simulations Plus company.

3. Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite;Agarwal;PLoS One,2008

4. Psychotropic medications metabolized by cytochromes P450 (CYP) 2D6 enzyme and relevant drug interactions;Ayano;Clin. Pharmacol. Biopharm.,2016

5. Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia;Chen;Life Sci.,1990

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