Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass – Prediction of viscosity through protein–protein interaction measurements
Author:
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference42 articles.
1. Strategies and challenges for the next generation of therapeutic antibodies;Beck;Nat. Rev. Immunol.,2010
2. Measurements of protein–protein interactions by size exclusion chromatography;Bloustine;Biophys. J.,2003
3. Nonnative aggregation of an IgG1 antibody in acidic conditions: Part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates;Brummitt;J. Pharm. Sci.,2011
4. Long- and short-range electrostatic interactions affect the rheology of highly concentrated antibody solutions;Chari;Pharm. Res.,2009
5. Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor;Chi;Protein Sci.,2003
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