Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002-Reference-Cited by-同舟云学术

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Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

Published:2017-01 Issue: Volume:97 Page:170-181
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Goltsov Alexey,Tashkandi Ghassan,Langdon Simon P.,Harrison David J.,Bown James L.

Funder

Northwood Trust

Scottish Informatics and Computer Science Alliance

Concerted Action CASyM

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference58 articles.

1. Considerations for the design and reporting of enzyme assays in high-throughput screening applications;Acker;Perspect. Sci.,2014

2. Characterization of the FKBP.rapamycin.FRB ternary complex;Banaszynski;J. Am. Chem. Soc.,2005

3. A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors;Bendell;Investig. New Drugs,2015

4. Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells;Brachmann;Proc. Natl. Acad. Sci. U. S. A.,2009

5. Calculation of inhibitor Ki and inhibitor type from the concentration of inhibitor for 50% inhibition for Michaelis-Menten enzymes;Brandt;Biochem. Med. Metab. Biol.,1987

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1. Stochastic formal model of PI3K/mTOR pathway in Alzheimer's disease for drug repurposing: An evaluation of rapamycin, LY294002, and NVP-BEZ235;Science of Computer Programming;2024-01

2. Queueing theory model of mTOR complexes’ impact on Akt-mediated adipocytes response to insulin;PLOS ONE;2022-12-27

3. Statistical Model Checking in Drug Repurposing for Alzheimer’s Disease;Lecture Notes in Computer Science;2020

4. Overexpressing cell systems are a competitive option to primary adipocytes when predicting in vivo potency of dual GPR81/GPR109A agonists;European Journal of Pharmaceutical Sciences;2018-03

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