The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation-Reference-Cited by-同舟云学术

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The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation

Published:2017-11 Issue: Volume:109 Page:S83-S89
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

de Witte W.E.A.,Vauquelin G.,van der Graaf P.H.,de Lange E.C.M.

Funder

European Union's Seventh Framework Programme

European Federation of Pharmaceutical Industries and Associations

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference22 articles.

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2. Application of a combined ‘effect compartment/indirect response model’ to the central nervous system effects of tiagabine in the rat;Cleton;J. Pharmacokinet. Biopharm.,1999

3. Effects of the geometry of the immunological synapse on the delivery of effector molecules;Coombs;Biophys. J.,2004

4. Drug-target residence time and its implications for lead optimization;Copeland;Nat. Rev. Drug Discov.,2006

5. Pharmacokinetics and the drug-target residence time concept;Dahl;Drug Discov. Today,2013

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