Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions

Author:

Piette Marie,Evrard Brigitte,Frankenne Francis,Chiap Patrice,Bertholet Pascal,Castagne Delphine,Foidart Jean-Michel,Delattre Luc,Piel Géraldine

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference37 articles.

1. Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model;Arlt;Cancer Res.,2002

2. The effect of cyclodextrins on the aqueous solubility of a new MMP inhibitor: phase solubility, 1H NMR spectroscopy and molecular modeling studies, preparation and stability study of nebulizable solutions;Bertholet;J. Pharm. Pharm. Sci.,2005

3. Pharmacokinetics, Principles and Applications;Boroujerdi,2002

4. The use of chemically modified cyclodextrins in the development of formulations for chemical delivery systems;Brewster;Pharmazie,2002

5. Automated method for the determination of a new matrix metalloproteinase inhibitor in ovine plasma and serum by coupling of restricted access material for on-line sample clean-up to liquid chromatography;Chiap;J. Chromatogr. B: Anal. Technol. Biomed. Life Sci.,2005

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