Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap

Author:

Umetsu Sarah E.,Kakar Sanjay,Basturk Olca,Kim Grace E.,Chatterjee Deyali,Wen Kwun Wah,Hale Gillian,Shafizadeh Nafis,Cho Soo-Jin,Whitman Julia,Gill Ryan M.,Jones Kirk D.,Navale Pooja,Bergsland Emily,Klimstra David,Joseph Nancy M.

Funder

University of California, San Francisco

Publisher

Elsevier BV

Subject

Pathology and Forensic Medicine

Reference53 articles.

1. Klimstra DSKG, La Rosa S, Rindi G. Classification of Neuroendocrine Neoplasms of the Digestive System. In: WHO Clasification of Tumours Editorial Board (ed). The World Health Organization (Who) Classificatio of Tumours: Digestive System Tumors (International Agency for Research on Cancer: Lyon (France). 2019.

2. Kloppel GCA, Hruban RH, Klimstra DS, et al. Neoplasms of the Neuroendocrine Pancreas. In: WHO Clasification of Tumours Editorial Board (ed). The World Health Organization (Who) Classificatio of Tumours of Endocrine Organs (International Agency for Research on Cancer: Lyon (France). 2017.

3. The high-grade (Who G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well-differentiated and poorly differentiated neoplasms;Basturk;Am J Surg Pathol,2015

4. A practical approach to the classification of Who Grade 3 (G3) well-differentiated neuroendocrine tumor (Wd-Net) and poorly differentiated neuroendocrine carcinoma (Pd-Nec) of the pancreas;Tang;Am J Surg Pathol,2016

5. Well-differentiated neuroendocrine tumors with a morphologically apparent high-grade component: a pathway distinct from poorly differentiated neuroendocrine carcinomas;Tang;Clin Cancer Res,2016

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