Pourquoi et comment mesurer et optimiser le dépôt pulmonaire des traitements inhalés ?

Author:

Devillier P.,Naline E.,Dubus J.-C.

Publisher

Elsevier BV

Subject

Pulmonary and Respiratory Medicine

Reference65 articles.

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2. Weda M, Zanen P, de Boer AH, Barends DM, Frijlink HW : The therapeutic index of locally acting drugs as a function of their fine particle mass and particle size distribution – a literature review. Curr Drug Deliv 2008 ; 5 : 142-7.

3. Guidance for industry – Nasal Spray and inhalation solution, suspension and spray drug products – chemistry, manufacturing, and controls documentation. CDER, US department of Health and Human Services, Food and Drug Administration, 2002.

4. Guidelines on the requirements for clinical documentation for orally inhaled products including the requirements for demonstration of therapeutic equivalence between two inhaled products for use in the treatment of asthma and chronic obstructive pulmonary disease. CPMP/EWP/4151/00. October 2007.

5. De boer AH, Gjaltema D, Hagedoorn P, Frijlink HW : Characterization of inhalation aerosols: a critical evaluation of cascade impactor analysis and laser diffraction technique. Int J Pharmaceutics 2002 ; 49 : 219-31.

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