Measurement of cytochrome P-450 dependent dealkylation of alkoxy-phenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol

Author:

Lubet Ronald A.,Nims Raymond W.,Mayer Richard T.,Cameron John W.,Schechtman Leonard M.

Publisher

Elsevier BV

Subject

General Medicine

Reference10 articles.

1. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene;Burke;Drug Metab. Dispos.,1974

2. Inherent specificities of purified cytochromes P-450 and P-448 toward biphenyl hydroxylation and ethoxyresorufin deethylation;Burke;Drug. Metab. Dispos.,1975

3. Characteristics of a microsomal cytochrome P-448-mediated reaction, ethoxyresorufin O-deethylation;Burke;Drug. Metab. Dispos.,1977

4. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions;Pohl;Anal. Biochem.,1980

5. Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxy resorufins);Burke;Chem.-Biol. Interact.,1983

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