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Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy

  • Published:2016-08 Issue:8 Volume:1863 Page:2065-2071
  • ISSN:0167-4889
  • Container-title:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • language:en
  • Short-container-title:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Author:

Kruspig Björn,Valter Kadri,Skender Belma,Zhivotovsky Boris,Gogvadze Vladimir

Funder

Russian Science Foundation

Swedish Research Council

Swedish

Stockholm

Swedish Childhood Cancer Foundation

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference37 articles.

1. ROS stress in cancer cells and therapeutic implications;Pelicano;Drug Resist. Updat.,2004

2. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate;Trachootham;Cancer Cell,2006

3. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression;Harris;Cancer Cell,2015

4. Mitochondrial complex II has a key role in mitochondrial-derived reactive oxygen species influence on plant stress gene regulation and defense;Gleason;Proc. Natl. Acad. Sci. U. S. A.,2011

5. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis;Ishii;Cancer Res.,2005
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