The negligible systemic availability of retinoids with multiple and excessive topical application of isotretinoin 0.05% gel (Isotrex) in patients with acne vulgaris

Author:

Jensen Bradford K.,McGann Linda Ann,Kachevsky Valentina,Franz Thomas J.

Publisher

Elsevier BV

Subject

Dermatology

Reference12 articles.

1. Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid;Peck;N Engl J Med,1979

2. Retinoids: a review;Dicken;J Am Acad Dermatol,1984

3. Efficacy of topical isotretinoin 0.05% gel in acne vulgaris: results of a multicenter, double-blind investigation;Chalker;J Am Acad Dermatol,1987

4. Isotretinoin embryopathy and the cranial neural crest: an in vivo and in vitro study;Webster;J Craniofac Genet Dev Biol,1986

5. Determination of isotretinoin or etretinate and their major metabolites in human blood by reversed-phase high-performance liquid chromatography;Bugge;J Pharm Biomed Anal,1985

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