A new look at the hemolytic effect of local anesthetics, considering their real membrane/water partitioning at pH 7.4

Author:

Malheiros Sônia V.P,Pinto Luciana M.A,Gottardo Luciane,Yokaichiya Daniela K,Fraceto Leonardo F,Meirelles Nilce C,de Paula Eneida

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Biophysics

Reference41 articles.

1. Local Anesthetics: Mechanisms of Action and Clinical Use;Covino,1976

2. Differential nerve-blockade: esters vs. amides and the influence of pKa;Wildsmith;Br. J. Anaesth.,1987

3. Molecular mechanisms of local anesthesia: a review;Butterworth;Anesthesiology,1990

4. Local Anesthetics;de Jong,1994

5. Quantitative structure–activity relationship studies on local anesthetics;Gupta;Chem. Rev.,1991

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