Inhibitors of sterol synthesis. A highly efficient and specific side-chain oxidation of 3 beta-acetoxy-5 alpha-cholest-8(14)-en-15-one for construction of metabolites and analogs of the 15-ketosterol.

Author:

Herz JE,Swaminathan S,Pinkerton FD,Wilson WK,Schroepfer GJ

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Biochemistry

Reference65 articles.

1. Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols;Schroepfer;J. Biol. Chem.,1977

2. 5α-Cholest-8 (14)-en-3β-ol-15-one, a potent inhibitor of sterol synthesis, reduces the levels of activity of enzymes involved in the synthesis and reduction of 3-hydroxy-3-methylglutaryl coenzyme A in CHO-K1 cells;Miller;Biochem. Int.,1980

3. 14α-Ethyl-5α-cholest-7-ene-3β,15α-diol, a potent inhibitor of sterol biosynthesis, has two sites of action in cultured mammalian cells;Pinkerton;J. Biol. Chem.,1982

4. Inhibitors of sterol synthesis. Studies of the metabolism of 5α-cholest- 8 ( 14 ) -en-3β-ol-15-one in Chinese hamster ovary cells and its effects on activities of early enzymes in cholesterol biosynthesis;Pąjewski;Chem. Phys. Lipids.,1988

5. 5α-Cholest-8 (14)-en-3β-ol-15-one. A competitive substrate for acyl coenzyme A:cholesterol acyl transferase;Miller;Biochem. Biophys. Res. Commun.,1987

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