QSAR-guided pharmacophoric modeling reveals important structural requirements for Polo kinase 1 (Plk1) inhibitors

Author:

Shahin RandORCID,AL-Hashimi Nabil N.ORCID,Daoud Nour el-HudaORCID,Aljamal SalahORCID,Shaheen Omar

Funder

Hashemite University

Zarqa University

National Cancer Institute

Deanship of Scientific Research, King Saud University

Publisher

Elsevier BV

Subject

Materials Chemistry,Computer Graphics and Computer-Aided Design,Physical and Theoretical Chemistry,Spectroscopy

Reference67 articles.

1. Non-mitotic functions of polo-like kinases in cancer cells;Raab;BBA - Rev. Canc.,2020

2. Molecular and enzoinformatics perspectives of targeting Polo-like kinase 1 in cancer therapy;Shakil;Semin. Canc. Biol.,2017

3. A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1;Ahn;J. Med. Chem.,2015

4. MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate;Abdelfatah;Acta Pharm. Sin. B.,2019

5. Structure of the catalytic domain of human polo-like kinase 1;Kothe;Biochemistry,2007

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