Biased agonists differentially modulate the receptor conformation ensembles in Angiotensin II type 1 receptor

Author:

Nivedha Anita K.ORCID,Lee SangbaeORCID,Vaidehi NagarajanORCID

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Materials Chemistry,Computer Graphics and Computer-Aided Design,Physical and Theoretical Chemistry,Spectroscopy

Reference32 articles.

1. Angiotensin II–stimulated signaling through G proteins and β-arrestin;Shenoy;Sci. Signal.,2005

2. Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT 1 receptor with protective action in cardiac hypertrophy;Teixeira;Sci. Rep.,2017

3. Recent developments in biased agonism;Wisler;Curr. Opin. Cell Biol.,2014

4. Teaching old receptors new tricks: biasing seven-transmembrane receptors;Rajagopal;Nat. Rev. Drug Discov.,2010

5. Functional selectivity and classical concepts of quantitative pharmacology;Urban;J. Pharmacol. Exp. Therapeut.,2007

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