Inflammasome Activation Is Reactive Oxygen Species Dependent and Mediates Irinotecan-Induced Mucositis through IL-1β and IL-18 in Mice

Author:

Arifa Raquel D.N.,Madeira Mila F.M.,de Paula Talles P.,Lima Renata L.,Tavares Livia D.,Menezes-Garcia Zélia,Fagundes Caio T.,Rachid Milene A.,Ryffel Bernhard,Zamboni Dario S.,Teixeira Mauro M.,Souza Danielle G.

Funder

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Elsevier BV

Subject

Pathology and Forensic Medicine

Reference55 articles.

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2. First-line chemotherapy with irinotecan plus capecitabine for advanced colorectal cancer;Park;Oncology,2004

3. First-line treatment with capecitabine combined with irinotecan in patients with advanced colorectal carcinoma: a phase II study;Assy;J Clin Gastroenterol,2012

4. Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions;Slatter;Drug Metab Dispos,1997

5. Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients;Slatter;Drug Metab Dispos,2000

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