Role of Human Liver P450s and Cytochrome b5 in the Reductive Metabolism of 3′-Azido-3′-deoxythymidine (AZT) to 3′-Amino-3′-deoxythymidine

Author:

Pan-Zhou Xin-Ru,Cretton-Scott Erika,Zhou Xiao-Jian,Yang Ming-Xue,Lasker Jerome M.,Sommadossi Jean-Pierre

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference53 articles.

1. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase;Furman;Proc Natl Acad Sci USA,1986

2. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex;Richman;N Engl J Med,1987

3. Zidovudine-associated myopathy;Helbert;Lancet,1988

4. Mitochondrial myopathy caused by long-term zidovudine therapy;Dalakas;N Engl J Med,1990

5. Cellular pharmacology of 3′-azido-3′-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells;Sommadossi;Mol Pharmacol,1989

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