Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by anvirzel and its cardiac glycoside component, oleandrin11Abbreviations: PARP, poly(ADP-ribose) polymerase; NF-κB, nuclear factor-κB; FGF-2, fibroblast growth factor-2; ER, endoplasmic reticulum; and MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.

Author:

Smith Judith A,Madden Timothy,Vijjeswarapu Mary,Newman Robert A

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference16 articles.

1. Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells;McConkey;Cancer Res,2000

2. Oleandrin suppresses activation of nuclear transcription factor-κB, activator protein-1, and c-Jun NH2-terminal kinase;Manna;Cancer Res,2000

3. Cardiac glycosides in the next millennium;Hauptman;Prog Cardiovasc Dis,1999

4. Understanding the sodium pump and its relevance to disease;Rose;Clin Chem,1994

5. The inhibition of fibroblast growth factor-2 export by cardenolides implies a novel function for the catalytic subunit of Na+,K+-ATPase;Florkiewicz;J Biol Chem,1998

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