Gγ-like (ggl) domains: new frontiers in g-protein signaling and β-propeller scaffolding22Abbreviations: DEP, dishevelled/EGL-10/pleckstrin-related domain; DH, dbl-homology domain; GAP, guanosine triphosphatase-activating protein; GEF, guanine nucleotide exchange factor; GGL, G-gamma-like; GIRK, G-protein-gated inwardly rectifying potassium channel; GPCR, G-protein-coupled receptor; G protein, guanine nucleotide binding protein; GTPase, guanosine triphosphatase; mAChR, muscarinic acetylcholine receptor; MAPK, mitogen-activated protein kinase; PDE, phosphodiesterase; PDZ, PSD-95/Discs-large/ZO-1 related domain; PH, pleckstrin-homology domain; PI3Kγ, gamma isoform of phosphoinositide 3-kinase; PLC-β, beta isoform of phospholipase C; PTB, phosphotyrosine-binding domain; RACK1, receptor for activated C kinase type-1; RBD, Ras-binding domain; RGS, regulators of G-protein signaling; and SAPK, stress-activated protein kinase.