Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin11Abbreviations: AA, arachidonic acid; ACO, acyl-CoA oxidase; COX; cyclooxygenase; NSAIDs, nonsteroidal anti-inflammatory drugs; PGHS, prostaglandin endoperoxide H synthase; PPP, platelet-poor plasma; PRP, platelet-rich plasma; PPAR, peroxisome proliferator-activated receptor; PPRE, peroxisome proliferator response element; and CoA coenzyme A.

Author:

Jaradat Maisa S,Wongsud Buanus,Phornchirasilp Srichan,Rangwala Shamina M,Shams Gamal,Sutton Melissa,Romstedt Karl J,Noonan Daniel J,Feller Dennis R

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference53 articles.

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2. Nonsteroidal anti-inflammatory drugs;Borne,1995

3. Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats;Mukherjee;Inflamm Res,1996

4. Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes;Miyamoto;J Biol Chem,1976

5. Cloning two isoforms of rat cyclooxygenase;Feng;Arch Biochem Biophys,1993

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