The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22-18O] 20, 22-dihydroxycholesterols, [18O] isocaproaldehyde, [18O] water and atmospheric [18O] oxygen
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Reference15 articles.
1. Biosynthesis of Pregnane Derivatives
2. Intermediates in the conversion of cholesterol to pregnenolone: Kinetics and mechanism
3. Stereochemical specificity at carbon-20 and -22 of hydroxylated cholesterols for side-chain cleavage by adrenocortical cytochrome P -450scc
4. The role of mitochondrial cytochrome P-450 from bovine adrenal cortex in side chain cleavage of 20S,22R-dihydroxycholesterol.
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1. Transcriptome Analysis and Identification of the Cholesterol Side Chain Cleavage Enzyme BbgCYP11A1 From Bufo bufo gargarizans;Frontiers in Genetics;2022-04-05
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3. Quantum-Mechanical/Molecular-Mechanical Studies of CYP11A1-Catalyzed Biosynthesis of Pregnenolone from Cholesterol Reveal a C–C Bond Cleavage Reaction That Occurs by a Compound I-Mediated Electron Transfer;Journal of the American Chemical Society;2019-11-19
4. The Catalytic Mechanism of Steroidogenic Cytochromes P450 from All-Atom Simulations: Entwinement with Membrane Environment, Redox Partners, and Post-Transcriptional Regulation;Catalysts;2019-01-14
5. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system;Proceedings of the National Academy of Sciences;2011-06-02
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