Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity

Author:

Finch Rick A,Liu Mao-Chin,Grill Susan P,Rose William C,Loomis Regina,Vasquez Karen M,Cheng Yung-Chi,Sartorelli Alan C

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference34 articles.

1. Reduction of ribonucleotides;Thelander;Annu Rev Biochem,1979

2. Regulation of ribonucleotide reductase activity in mammalian cells;Cory;Mol Cell Biochem,1983

3. Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells;Thelander;J Biol Chem,1985

4. Ribonucleotide reductase and cell proliferation. 1. Variations of ribonucleotide reductase activity with tumor growth in a series of rat hepatomas;Elford;J Biol Chem,1970

5. Biochemical strategy of cancer cells and the design of chemotherapy;Weber;Cancer Res,1983

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