Clinical Use of Cyclosporine as an Adjunctive Therapy in the Management of Feline Idiopathic Pure Red Cell Aplasia

Author:

Viviano Katrina R1,Webb Julie L2

Affiliation:

1. Department of Medical Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, 2015 Linden Dr, Madison, WI 53711, USA

2. Department of Pathobiological Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI 53711, USA

Abstract

The clinical use of cyclosporine is described in a group of client-owned cats diagnosed with idiopathic pure red cell aplasia (PRCA). All 10 cats were treated with combinations of glucocorticoids and cyclosporine. Of the 10 cats, the eight for which follow-up data was available achieved and maintained remission for a median of 31 and 406 days, respectively. Therapy was reduced or discontinued in 7/8 cats; 2/7 maintained remission off therapy and 5/7 cats relapsed. Remission was reinduced in four cats, with 3/4 cats maintained long-term on low dose therapy. Adverse effects associated with cyclosporine therapy were responsive to dose reduction or drug withdrawal. Feline idiopathic PRCA was responsive to combination immunosuppressive therapy with glucocorticoids and cyclosporine. Relapse was common, particularly after drug discontinuation; therefore, most cats required maintenance long-term low dose therapy.

Publisher

SAGE Publications

Subject

Small Animals

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