Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol-Reference-Cited by-同舟云学术

Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol

Published:1988-01 Issue:1 Volume:46 Page:59-69
ISSN:0014-4835
Container-title:Experimental Eye Research
language:en
Short-container-title:Experimental Eye Research

Author:

Chang Shih-Chieh,Chien Du-Shieng,Bundgaard Hans,Lee Vincent H.L.

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology

Reference18 articles.

1. The ocular pharmacokinetics of eicosanoids and their derivatives. 1. Comparison of ocular eicosanoid penetration and distribution following the topical application of PGF2α, PGF2α-1-methyl ester, and PGF2α-1-isopropyl ester;Bito;Exp. Eye Res.,1987

2. Prodrugs of timolol for improved ocular delivery: synthesis, hydrolysis kinetics and lipophilicity of various timolol esters;Bundgaard;Int. J. Pharm.,1986

3. Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load;Chang;Invest. Ophthalmol. Vis. Sci.,1987

4. Nasal and conjunctival contributions to the systemic absorption of topical timolol in the pigmented rabbit: implications in the design of strategies to maximize the ratio of ocular to systemic absorption;Chang;J. Ocular Pharmacol.,1987

5. Lacrimal and instilled fluid dynamics in rabbit eyes;Chrai;J. Pharm. Sci.,1973

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