Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM×anti-CD3) as a targeted cancer immunotherapy

Author:

Seimetz Diane,Lindhofer Horst,Bokemeyer Carsten

Publisher

Elsevier BV

Subject

Radiology Nuclear Medicine and imaging,Oncology,General Medicine

Reference89 articles.

1. Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer;Ruf;Br J Cancer,2007

2. Simultaneous activation of T-cells and accessory cells by a new class of intact bispecific antibody results in efficient tumour cell killing;Zeidler;J Immunol,1999

3. The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells;Zeidler;Br J Cancer,2000

4. Lysis of prostate carcinoma cells by trifunctional bispecific antibodies (αEp-CAM×αCD3);Riesenberg;J Histochem Cytochem,2001

5. Opsonization with a trifunctional bispecific (αCD3×αEpCAM) antibody results in efficient lysis in vitro and in vivo of EpCAM positive tumour cells by cytotoxic T lymphocytes;Schmitt;Int J Oncol,2004

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