Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus

Author:

Fan Mingyue,Jin Wei,Zhao Haifeng,Xiao Yining,Jia Yanqiu,Yin Yu,Jiang Xin,Xu Jing,Meng Nan,Lv Peiyuan

Funder

National Natural Science Foundation of China

Hebei Province Major Medical Research Project of China

Hebei Province Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Behavioral Neuroscience

Reference40 articles.

1. Lithium up-regulates the cytoprotective protein Bcl-2 in the cns in vivo: a role of neurotrophic and neuroprotective effects in manic depressive illness;Manji;J. Clin. Psychiatry,2000

2. Excellent lithium responders have normal cognitive functions and plasma BDNF levels;Rybakowski;Int. J. Neuropsychopharmacol.,2010

3. Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia;Yan;Neuropharmacology,2007

4. Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils;Bian;Brain Res.,2007

5. Lithium potential therapeutics against acute brain injuries and chronic neurodegenerative diseases;Wada;J. Pharmacol. Sci.,2005

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