A phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: Toxicity and pharmacokinetics

Author:

Newman Hugh F.V.,Bleehen Norman M.,Workman Paul

Publisher

Elsevier BV

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,Radiation

Reference10 articles.

1. Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole;Brown;Radiat. Res.,1980

2. SR 2508: A 2-nitroimidazole anide which should be superior to misonidazole as a radiosensitizer for clinical use;Brown;Int. J Radiat. Oncol. Biol. Phys.,1981

3. Initial report of the phase I trial of the hypoxic cell radiosensitizer SR 2508;Coleman;Int. J. Radiat. Oncol. Biol. Phys.,1984

4. Cellular uptake of misonidazole and analogues with acidic or basic functions;Dennis;Int. J. Radiat. Biol. Phys.,1985

5. HPLC analysis of Ro 03-8799 in biological samples;Malcolm;J. Chromatog.,1983

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1. Hypoxia Mediates Tumor Malignancy and Therapy Resistance;Advances in Experimental Medicine and Biology;2019

2. Radiosensitization by the Combination of SR-2508 and Paclitaxel in Hypoxic Human Tumor Cells in vitro;Journal of Radiation Research;2007

3. Assessment of a range of novel nitro-aromatic radiosensitizers and bioreductive drugs;International Journal of Radiation Oncology*Biology*Physics;1992-01

4. Radiosensitization by the combination of etanidazole (SR-2508) and pimonidazole (Ro 03-8799) in human tumor xenografts;International Journal of Radiation Oncology*Biology*Physics;1991-11

5. A comparison of radiosensitization by etanidazole and pimonidazole in mouse tumors;International Journal of Radiation Oncology*Biology*Physics;1991-05

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