The dual trigger study: Rationale and study design of a prospective double-blind randomized clinical trial comparing pregnancy rates after co-administration of low dose hCG at the time of GnRH agonist trigger or 35 h later for the prevention of OHSS
Author:
Funder
Merck Sharp & Dohme (MSD) Corp., Roseland, New Jersey. USA
Publisher
Elsevier BV
Subject
Pharmacology,General Medicine
Reference24 articles.
1. The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study
2. Copenhagen Gn RHATWG. GnRH agonist for triggering of final oocyte maturation: time for a change of practice?;Humaidan;Hum. Reprod. Update,2011
3. Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology;Youssef;Cochrane Database Syst. Rev.,2014
4. Luteolysis induced by a gonadotropin-releasing hormone agonist is the key to prevention of ovarian hyperstimulation syndrome;Kol;Fertil. Steril.,2004
5. GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study;Humaidan;Hum. Reprod.,2005
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1. hCG Administration in Luteal Rescue: Intracavitary or Subcutaneously in Agonist Induced Ovulation in IVF Cycles;Clinical and Experimental Obstetrics & Gynecology;2023-05-22
2. Gonadotropin-releasing hormone agonist (alone or combined with human chorionic gonadotropin) vs. human chorionic gonadotropin alone for ovulation triggering during controlled ovarian stimulation for in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis;F&S Reviews;2021-10
3. Independent serum markers of corpora lutea function after gonadotropin-releasing hormone agonist trigger and adjuvant low dose human chorionic gonadotropin in in vitro fertilization;Fertility and Sterility;2019-09
4. Low dose human chorionic gonadotropin administration at the time of gonadotropin releasing-hormone agonist trigger versus 35 h later in women at high risk of developing ovarian hyperstimulation syndrome – a prospective randomized double-blind clinical trial;Journal of Ovarian Research;2019-01-26
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