Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats

Author:

Hagiwara Akihiro,Imai Norio,Doi Yuko,Nabae Kyoko,Hirota Takeshi,Yoshino Hiroko,Kawabe Mayumi,Tsushima Yoko,Aoki Hiromitsu,Yasuhara Kazuo,Koda Takatoshi,Nakamura Mikio,Shirai Tomoyuki

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference53 articles.

1. Annatto: a natural choice;Evans;Biologist (London),2000

2. Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice;Fernandes;J. Nutr. Biochem.,2002

3. The safety and regulatory status of food, drug and cosmetics color additives exempt from certification;Hallagan;Food Chem. Toxicol.,1995

4. Evaluation of the genotoxicity of some natural food colours using bacterial assays;Haveland-Smith;Mutat. Res.,1981

5. JECFA toxicological evaluation of certain food additives, Twenty-sixth Report of the Joints FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series No. 17 (1982) 22–27.

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